Recombinant Human Interleukin-17B protein (IL17B)
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中文名稱:人IL17B重組蛋白
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品名簡稱:Recombinant Human IL17B protein (Active)
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貨號:CSB-AP001651HU
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說明書:
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規格:¥852
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圖片:
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其他:
產品詳情
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純度:>95% as determined by SDS-PAGE.
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內毒素:Less than 1.0 EU/μg as determined by LAL method.
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生物活性:Fully biologically active when compared to standard. The ED50 as determined by inducing IL-8 secretion of human HepG2 cells is less than 1.0 μg/ml, corresponding to a specific activity of >1000 IU/mg.
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基因名:
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Uniprot No.:
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別名:Cytokine like protein Zcyto7; Cytokine Zcyto7; IL 17B; IL 20 ; IL-17B; IL-20; IL17B; IL17B_HUMAN; IL20 ; Interleukin 17 beta; Interleukin 17B; Interleukin 20; Interleukin-17B; Interleukin-20; MGC138900; MGC138901; Neuronal interleukin 17 related factor ; Neuronal interleukin-17-related factor; NIRF ; ZCYTO7
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種屬:Homo sapiens (Human)
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蛋白長度:Full Length of Mature Protein
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來源:E.Coli
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分子量:18.3 kDa
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表達區域:21-180aa
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氨基酸序列M+QPRSPKSKR KGQGRPGPLA PGPHQVPLDL VSRMKPYARM EEYERNIEEM VAQLRNSSEL AQRKCEVNLQ LWMSNKRSLS PWGYSINHDP SRIPVDLPEA RCLCLGCVNP FTMQEDRSMV SVPVFSQVPV RRRLCPPPPR TGPCRQRAVM ETIAVGCTCI F
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蛋白標簽:Tag-Free
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產品提供形式:Liquid or Lyophilized powder
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緩沖液:0.2 μm filtered PBS, pH 7.4, with 0.1 % Tween-20 and 3 % Trehalose ,lyophilized
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儲存條件:Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質期:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期:5-10 business days
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Datasheet & COA:Please contact us to get it.
相關產品
靶點詳情
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功能:Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.
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基因功能參考文獻:
- The results indicate that the IL-17B/IL-17RB signaling can promote the growth and migration of tumor cells. PMID: 27146881
- Our data revealed a new mechanism that IL-17B enhanced the progression of gastric cancer by activating mesenchymal stem cells. PMID: 28145881
- Segregation analysis revealed that variants c.475T>G in SKP1, c.671G>A in PROB1, and c.527G>A in IL17B in the 5q31.1-q35.3 linkage region, and c.850G>A in HKDC1 in the 10q22 locus completely segregated with the phenotype in the studied Keratoconus family PMID: 27703147
- This comprehensive review details the recognition of activity, signaling, and the roles of IL17B-IL17RB in breast cancer have caused to determination of new therapeutic mechanisms--{REVIEW} PMID: 28160754
- Studies indicate that interleukin 17 (IL-17B)/interleukin 17 receptor B (IL-17RB) signaling is essential for pancreatic cancer malignancy. PMID: 26285835
- IL-17B-IL-17RB signaling promotes pancreatic cancer malignancy. PMID: 25732306
- Results show that amplified signaling of interleukin-17 receptor B (IL-17RB) and its ligand IL-17B promot tumorigenicity in breast cancer cells and impeded acinus formation in immortalized normal mammary epithelial cells. PMID: 23851503
- IL-17B can enhance the effects of TNF-alpha on the production of cytokines and chemokines that control immune cell trafficking and neutrophil homeostasis in the inflamed tissues. PMID: 24056520
- IL-17A, IL-17B, IL-17F and IL-23 in systemic lupus erythematosus patients were examined and the correlation between levels of the investigated cytokines and VEGF, PIGF, as well as number of endothelial cells, was investigated. PMID: 23661335
- expression and functional study of IL-17B PMID: 22394632
- IL-17 may play an important role in the occurrence of nasal polyps by overexpression. PMID: 16805377
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亞細胞定位:Secreted.
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蛋白家族:IL-17 family
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組織特異性:Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary.
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數據庫鏈接:
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