DUSP2 Antibody

說明書

中文名稱：

DUSP2兔多克隆抗體
貨號：

CSB-PA094054
規(guī)格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA094054(DUSP2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA094054(DUSP2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)

Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: CSB-PA094054(DUSP2 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
其他：

產(chǎn)品詳情
產(chǎn)品評價
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靶點詳情

產(chǎn)品詳情

Uniprot No.：

Q05923
基因名：

DUSP2
別名：

Dual specificity phosphatase 2 antibody; Dual specificity protein phosphatase 2 antibody; Dual specificity protein phosphatase PAC 1 antibody; Dual specificity protein phosphatase PAC-1 antibody; DUS2_HUMAN antibody; DUSP 2 antibody; DUSP2 antibody; PAC 1 antibody; PAC1 antibody; Serine/threonine specific protein phosphatase antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse
免疫原：

Synthetic peptide of Human DUSP2
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.
基因功能參考文獻：
1. Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2 has been reported. PMID: 28252035
2. hypoxia-induced IL-6 production in endometriotic lesions is mediated via downregulation of DUSP2, which causes aberrant activation of STAT3 signaling pathway and helps the endometriotic cells survive under the ectopic environment PMID: 28440564
3. Authors report that hypoxia-mediated downregulation of the dual specificity phosphatase 2 (DUSP2) is critical for the accumulation of CSC in colorectal cancer. PMID: 28652251
4. Hypoxia inhibits DUSP2 expression in colon cancer, leading to up-regulation of IL-8, which facilitates angiogenesis and tumour metastasis. PMID: 28026024
5. Our data show that aberrant epigenetic inactivation of DUSP2 occurs in carcinogenesis and that CTCF is involved in the epigenetic regulation of DUSP2 expression. PMID: 26833217
6. Highly recurrent mutation of DUSP2 is associated with nodular lymphocyte predominant Hodgkin lymphoma. PMID: 26658840
7. identified among the key genes in circulating monocytes that were altered by exercise PMID: 26207425
8. Data show that hypoxia promotes lapatinib resistance in ERBB2-positive breast cancer cells through activation of the MEK-ERK pathway a HIF-1-dependent manner via regulation of dual-specificity phosphatase 2 (DUSP2). PMID: 25596742
9. DUSP2 is an important molecule in endometrial physiology and that hypoxia-inhibited DUSP2 expression is a critical factor for the development of endometriosis. PMID: 21984126
10. Dipyridamole reduced expression of PAC-1 and CD62p in patients with malignant lymphoma. PMID: 20723301
11. DUSP2 is a key downstream regulator of HIF-1-mediated tumor progression and chemoresistance PMID: 21490398
12. During apoptosis, p53 activates transcription of PAC1 by binding to a palindromic site in the PAC1 promoter PMID: 12673251
13. relationships between the expression levels of CD61, CD63, and PAC-1 on the platelet surface and the incidences of acute rejection and tubular necrosis as well as the recovery of graft function after renal transplantation PMID: 12826159
14. variation in large granular lymphocyte leukemia PMID: 14680939
15. These results reveal a crucial role of PAC1 in E2F-1-directed apoptosis. PMID: 17471234
16. Induction of hypercortisolism in healthy volunteers was not associated with changes in the platelet activation marker PAC-1 or the number of circulating platelet-leucocyte aggregates. PMID: 18600034
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亞細胞定位：

Nucleus.
蛋白家族：

Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
組織特異性：

Expressed in hematopoietic tissues.
數(shù)據(jù)庫鏈接：

HGNC: 3068

OMIM: 603068

KEGG: hsa:1844

STRING: 9606.ENSP00000288943

UniGene: Hs.1183

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