ELP3 Antibody
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								中文名稱:ELP3兔多克隆抗體
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								貨號:CSB-PA930405
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								規格:¥1100
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								圖片:- 
														
														The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA930405(ELP3 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)
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														The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA930405(ELP3 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)
 
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								其他:
產品詳情
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											Uniprot No.:
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											基因名:ELP3
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											別名:DKFZp761L098 antibody; Elongation protein 3 homolog (S. cerevisiae) antibody; Elongation protein 3 homolog antibody; ELONGATION PROTEIN 3; S. CEREVISIAE; HOMOLOG OF antibody; elongator acetyltransferase complex subunit 3 antibody; Elongator complex protein 3 antibody; elp3 antibody; ELP3_HUMAN antibody; FLJ10422 antibody; hELP3 antibody; Hypothetical protein DKFZp761L098 antibody; Kat9 antibody
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											宿主:Rabbit
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											反應種屬:Human,Mouse
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											免疫原:Synthetic peptide of Human ELP3
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											免疫原種屬:Homo sapiens (Human)
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											標記方式:Non-conjugated
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											抗體亞型:IgG
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											純化方式:Antigen affinity purification
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											濃度:It differs from different batches. Please contact us to confirm it.
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											保存緩沖液:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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											產品提供形式:Liquid
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											應用范圍:ELISA,IHC
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											推薦稀釋比:Application Recommended Dilution ELISA 1:1000-1:2000 IHC 1:15-1:50 
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											Protocols:
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											儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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											貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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											用途:For Research Use Only. Not for use in diagnostic or therapeutic procedures.
相關產品
靶點詳情
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											功能:Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase. Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. Required for acetylation of GJA1 in the developing cerebral cortex.
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											基因功能參考文獻:- and CTU1/2, partner enzymes in U34 methoxycarbonylmethyl-2-thio tRNA modification, are up-regulated in human breast cancers and sustain metastasis. PMID: 27811057
- Promoter hypermethylation is an important mechanism of the transcriptional inactivation of ELP3 in invasive ductal breast carcinoma. PMID: 25148870
- Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress. PMID: 24769394
- data suggest that hElp3 can regulate the transcription of HSP70 gene, and the HAT domain of hElp3 is essential for this function PMID: 22216241
- The results of this study uncover a novel role for Elp3 in the regulation of synaptic bouton expansion during neurogenesis that may be linked with a requirement for sleep. PMID: 20626565
- Elp3 promotes the acetylation of alpha-tubulin in microtubules in neurological disorders. PMID: 20036197
- We used hELP3 antisense oligonucl. to knock down hELP3 gene. The results showed that reduction of hELP3 mRNA and protein caused a suppression of HSP70-2 and histone H3 hypoacetylation. PMID: 17558451
- Allelic variants of ELP3 were associated with amyotrophic lateral sclerosis in three populations comprising 1483 people. PMID: 18996918
- ELP3 localises to mitochondria in HeLa cells, actin-like filaments, and actin-rich sites at the edges of spreading cells. This suggests that ELP3 and the ELONGATOR complex may play a role in mitochondrial function, actin organisation, and cell motility. PMID: 19429107
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											相關疾病:ELP3 genetic variations may be associated with an increased risk for neurodegeneration and motor neuron diseases.
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											亞細胞定位:Cytoplasm. Nucleus.; [Isoform 1]: Nucleus.; [Isoform 2]: Cytoplasm. Nucleus.
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											蛋白家族:ELP3 family
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											組織特異性:Expressed in the cerebellum and spinal motor neurons.
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											數據庫鏈接:
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