Recombinant Mouse Interleukin-7 receptor subunit alpha (Il7r), partial

中文名稱：

小鼠Il7r重組蛋白
品名簡稱：

Recombinant Mouse Il7r protein, partial
貨號(hào)：

CSB-EP011670MO
說明書：

MSDS Datasheet
規(guī)格：

￥2328
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

Il7r
Uniprot No.：

P16872
別名：

Il7r; Interleukin-7 receptor subunit alpha; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7R-alpha; IL-7RA; CD antigen CD127
種屬：

Mus musculus (Mouse)
蛋白長度：

Extracellular Domain
來源：

E.coli
分子量：

41.0kDa
表達(dá)區(qū)域：

21-239aa
氨基酸序列

ESGNAQDGDLEDADADDHSFWCHSQLEVDGSQHLLTCAFNDSDINTANLEFQICGALLRVKCLTLNKLQDIYFIKTSEFLLIGSSNICVKLGQKNLTCKNMAINTIVKAEAPSDLKVVYRKEANDFLVTFNAPHLKKKYLKKVKHDVAYRPARGESNWTHVSLFHTRTTIPQRKLRPKAMYEIKVRSIPHNDYFKGFWSEWSPSSTFETPEPKNQGGWD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 6xHis-SUMO-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
基因功能參考文獻(xiàn)：
1. Memory formation and long-term maintenance of memory type I innate lymphoid cells via a lymph node-liver axis is mediated via IL-7Ralpha expression. PMID: 30451860
2. IL-7 receptor (IL-7R) is not strictly required for the development of any innate lymphoid cells subset. PMID: 28361874
3. the results indicate that endogenous IL-7R signals promote Th1 and Tc1 responses and IFN-gamma- and TNF-alpha production to sustain the persistence of SS-like sialadenitis in NOD mice. These findings suggest that IL-7 and Th1 cytokines could serve as promising therapeutic targets for this prevalent autoimmune disease. PMID: 29680668
4. this study demonstrates a key role for IL-7R in the generation of microenvironments required for thymic dendritic cells PMID: 28890536
5. show that the differentiation of group 3 ILCs is controlled by the glutamylation of IL-7Ralpha and the induction of transcription factor Sall3 PMID: 28794449
6. results demonstrated that forced expression of IL-7R not only improved the functionality of tolerized CD8 T cells, it also acted in synergy with PDL-1 deficiency to further promote CD8 T cell cytotoxicity to self antigens PMID: 29272267
7. this study shows that short-term blockade of IL-7Ralpha induces detectable changes in co-inhibitory receptor expression and Treg frequencies in peripheral blood of NOD mice PMID: 28356069
8. results indicate that the induction of IL-7Ralpha expression on dendritic cells (DCs) is critical for thymic stromal lymphopoietin responsiveness and that IL-4 can upregulate IL-7Ralpha on DCs. PMID: 28404633
9. IL-7RA role in hematopoiesis and development of the lympho-myeloid progenitors in the developing fetal liver PMID: 26235516
10. These studies provide in vivo evidence that IL-7Ralpha signals positively regulate normal human B-cell production and proliferation beyond the fetal period and suggest that TSLP can replace IL-7 in providing these signals. PMID: 27325567
11. Bcl6 promoted T follicular helper cell differentiation through antagonizing IL-7R / STAT5a axis. PMID: 26876184
12. results suggest that LNK suppresses IL-7R/JAK/STAT signaling to restrict pro-/pre-B progenitor expansion and leukemia development, providing a pathogenic mechanism and a potential therapeutic approach for B-ALLs with LNK mutations. PMID: 26974155
13. The IL-7R plays an important role in the induction of HFD-induced adipogenesis and insulin resistance in mice. PMID: 26152662
14. IL-7R signaling in regulatory T cells maintains peripheral and allograft tolerance in mice. PMID: 26450881
15. This work demonstrates that the CNS1 element controls IL-7Ralpha expression and maintenance of peripheral T cells, suggesting differential regulation of IL-7Ralpha expression between central and peripheral lymphoid organs. PMID: 26336149
16. Inhibition of the IL-7 receptor inhibits tumor growth in murine models of melanoma. PMID: 24619454
17. The combined loss of Gads and CD127 reveals a novel function of Gads prior to T cell receptor beta expression PMID: 25037454
18. data suggest that IL-7Ralpha Tyr(449) was essential for IL-7Ralpha signaling in bone marrow B cell development and survival. PMID: 25143441
19. The development and survival but not function of follicular B cells is dependent on IL-7Ralpha Tyr449 signaling. PMID: 24551160
20. interleukin-7 receptor mutants induce early T cell precursor acute lymphoblastic leukemia by the block of thymocyte differentiation at the double negative 2 stage at which myeloid lineage and T lymphocyte developmental potential coexist. PMID: 24687960
21. The transcription factor GATA3 is critical for the development of all IL-7Ralpha-expressing innate lymphoid cells. PMID: 24631153
22. Expression of insertion mutation in combination with a Notch1 mutant led to the development of much more aggressive T-acute lymphoblastic leukemia than with wild-type IL7Ralpha. PMID: 24174626
23. These data indicate that IL7R+ B cells have a proinflammatory role in arthritis which can be inhibited by the sympathetic neurotransmitter norepinephrine via inhibition of IL-7R signalling. PMID: 23505234
24. IL-7Ralpha transgenesis or T-cell-specific ablation of Gfi-1 restored IL-7Ralpha expression and largely ameliorated the development and homeostasis defects of TGF-beta-receptor-deficient T cells. PMID: 23932572
25. We have analyzed the discrete contributions of the antibody constant (Fc) and IL-7-binding (Fab) domains to the mechanism of binding to IL-7R. PMID: 23610371
26. IL7Ralpha has a role in potentiating IL-7 bioactivity and in promoting autoimmunity PMID: 23610432
27. Pre-B cell receptor (BCR) cooperates with IL-7R in expanding the pre-B cell pool, but it also critically controls the differentiation program that shuts off the c-Myc gene in large pre-B cells. PMID: 23420891
28. IL-7Ralpha differentially controls development and maturation of thymocyte subpopulations in late developmental stages. PMID: 23267098
29. the in vivo regulatory role of Gfi1 was specific for CD8(+), and not CD4(+) T cells or immature thymocytes. These results identify Gfi1 as a specific transcriptional repressor of the Il7r gene in CD8 T lymphocytes in vivo. PMID: 22865857
30. show that interleukin-17A (IL-17A)-producing IL-7Ralpha(+) innate lymphoid cells (ILCs) were potent promoters of disease in Tbx21(-/-)Rag2(-/-) ulcerative colitis (TRUC) mice PMID: 23063332
31. The durable efficacy and the multipronged tolerogenic mechanisms of IL-7Ralpha antibody therapy suggest a unique disease-modifying approach to T1D. PMID: 22733769
32. Blockade of IL-7/IL-7Ralpha signaling in IL-7-dependent p53(null) cells reduced POT1 expression and caused telomere and chromosome abnormalities similar to those observed in DKO lymphomas. PMID: 22281704
33. Data suggest that this decrease in IL-7Ralpha is associated with defective hematopoietic development in Down Syndrome. PMID: 21504363
34. Increased IL-7Ralpha (CD127) expression correlated, as previously reported with increased turnover of CD4 memory cells, however, this was not linked to protection or enhanced response to rechallenge PMID: 22039531
35. a novel function of Efnb1 and Efnb2 in stabilizing IL-7Ralpha expression at the post-translational level PMID: 22069310
36. IL-7R-mediated signaling not only maintains the size but also impacts the diversity of the naive T-cell repertoire. PMID: 21339767
37. IL-7R-dependent survival and differentiation of early T-lineage progenitors is regulated by the BTB/POZ domain transcription factor Miz-1. PMID: 21258009
38. High expression of IL-7 receptor (IL-R)alpha on colitic CD4-positive memory T cells, but not on other cells, is essential for the development and persistence of chronic colitis. PMID: 21217010
39. These findings highlight that IL-7Ralpha confers susceptibility by influencing autoimmune Th1/Th17 responses in experimental autoimmune encephalomyelitis model of multiple sclerosis . PMID: 20861865
40. T-cell homeostasis is maintained through a concerted regulation of Gfi-1-IL-7R-controlled cytokine responsiveness and ERK-mediated TCR signaling strength by the Cdc42-PAK1 signaling axis. PMID: 20937872
41. increased expression on activated FOXP3+CD4+ regulatory T cells PMID: 20690182
42. HIV Tat protein colocalizes with CD127 at the cell surface of resting CD8-positive T lymphocytes. PMID: 20660706
43. Sin1-mTORC2 suppresses rag1,2 and il7r gene expression through Akt2 in B cells. PMID: 20705244
44. study shows that IL-7Ralpha Y449 is important for lymphocyte transformation PMID: 20440272
45. Pre-pro-B cell growth-stimulating factor (PPBSF) upregulates IL-7Ralpha chain expression and enables pro-B cells to respond to monomeric IL-7. PMID: 12184921
46. IL-7R(alpha)(-/-) mice lack detectable numbers of all downstream early B lineage precursors, including pre-pro-B cells PMID: 12208884
47. IL-7R signals are able to stimulate T cell proliferation in lymphopenic hosts independently of lck-mediated T cell receptor (TCR) signaling, but they can also synergize with TCR signals to facilitate proliferation. PMID: 12244169
48. IL-2 signaling can diminish IL-7Ralpha expression via a phosphatidylinositol 3-kinase/Akt-dependent mechanism. PMID: 12354940
49. The inability of B-cell progenitors in the thymus to mature is due to down-regulation of IL7Ralpha through a type 1 IFN receptor-independent mechanism PMID: 12393710
50. Bax deficiency partially corrects interleukin-7 receptor alpha deficiency PMID: 12433363
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亞細(xì)胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

Type I cytokine receptor family, Type 4 subfamily
組織特異性：

Spleen, thymus and fetal liver.
數(shù)據(jù)庫鏈接：

KEGG: mmu:16197

STRING: 10090.ENSMUSP00000003981

UniGene: Mm.389