Recombinant Rat Glypican-1 (Gpc1)

中文名稱：

大鼠Gpc1重組蛋白
貨號(hào)：

CSB-YP009703RA
規(guī)格：
來源：

Yeast
其他：

中文名稱：

大鼠Gpc1重組蛋白
貨號(hào)：

CSB-EP009703RA
規(guī)格：
來源：

E.coli
其他：

中文名稱：

大鼠Gpc1重組蛋白
貨號(hào)：

CSB-EP009703RA-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Gpc1重組蛋白
貨號(hào)：

CSB-BP009703RA
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Gpc1重組蛋白
貨號(hào)：

CSB-MP009703RA
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Gpc1
Uniprot No.：

P35053
別名：

Gpc1Glypican-1; HSPG M12) [Cleaved into: Secreted glypican-1]
種屬：

Rattus norvegicus (Rat)
蛋白長(zhǎng)度：

Full Length of Mature Protein
表達(dá)區(qū)域：

24-530
氨基酸序列

DPASKSR SCSEVRQIYG AKGFSLSDVP QAEISGEHLR ICPQGYTCCT SEMEENLANH SRMELETALH DSSRALQATL ATQLHGIDDH FQRLLNDSER TLQDAFPGAF GDLYTQNTRA FRDLYAELRL YYRGANLHLE ETLAEFWARL LERLFKQLHP QLLLPDDYLD CLGKQAEALR PFGDAPRELR LRATRAFVAA RSFVQGLGVA SDVVRKVAQV PLAPECSRAV MKLVYCAHCR GVPGARPCPD YCRNVLKGCL ANQADLDAEW RNLLDSMVLI TDKFWGPSGA EYVIGSVHMW LAEAINALQD NKDTLTAKVI QGCGNPKVNP HGSGPEEKRR RAKLALQEKS STGTLEKLVS EAKAQLRDIQ DYWISLPGTL CSEKMAMSPA SDDRCWNGIS KGRYLPEVMG DGLANQINNP EVEVDITKPD MTIRQQIMQL KIMTNRLRGA YGGNDVDFQD ASDDGSGSGS GGGCPDDACG RRVSKKSSSS RTPLIHALPG LSEQEGQKTS
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Cell surface proteoglycan that bears heparan sulfate. May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. Binds Cu(2+) or Zn(2+) ions. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination.
基因功能參考文獻(xiàn)：
1. These data suggest that fluid shear stress induced the cell junctional clustering of lipid rafts with their anchored glypican-1 and associated HS. PMID: 23851278
2. Glypican increased fibroblast growth factor-2 expression and neurite extension in cortical neuron cultures. PMID: 22615373
3. Suggest that membrane proteoglycans glypican-1/syndecan-4 participate in the sequence of events triggered by diabetes and inflicted on cardiac and skeletal muscles. PMID: 21518435
4. conclusion, gpc-1 expression in odontoblast-like cells is associated with the early differentiation but not with the formation of reparative dentine. PMID: 20515442
5. Data suggest that glypican-1 acts as a positive regulator of muscle differentiation by sequestering FGF-2 in lipid rafts and preventing its binding and dependent signaling. PMID: 20100867
6. FSH, through its second messengers (increase in intracellular cAMP and intracellular calcium), downregulated the glypican-1 mRNA expression in Sertoli cells from 20-day-old rats. PMID: 12135485
7. Glypican-1 was coexpressed with slit2 mRNA in reactive astrocytes, suggesting that glypican-1 might also prevent regenerating axons from entering into brain lesions. PMID: 12655597
8. glypican-1 is involved in the neuronal-like differentiation of PC12 cells and could play an important role on the regeneration responses of peripheral nerves PMID: 12914968
9. glypican-1 heparan sulfate degradation in rat C6 glioma cells is regulated by ceruloplasmin PMID: 14707133
10. Glypican-1 mRNA is present in sensory neurons of the dorsal root ganglion of adult rats and is up-regulated after peripheral and central nerve injury. PMID: 15016071
11. Glypican-1 has an important role in peripheral nerve terminal differentiation. PMID: 16407548
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亞細(xì)胞定位：

Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Endosome.; [Secreted glypican-1]: Secreted, extracellular space.
蛋白家族：

Glypican family
組織特異性：

Nervous system.
數(shù)據(jù)庫(kù)鏈接：

KEGG: rno:58920

STRING: 10116.ENSRNOP00000066597

UniGene: Rn.7044