DDR1
盤狀結構域受體(DDRs)是一類受體型酪氨酸激酶(RTKs),可分為DDR1和DDR2,在細胞的黏附、增殖及細胞外基質的重塑中起重要作用。與其他酪氨酸蛋白激酶受體一樣,DDR1會在配體結合位點發生自體磷酸化。但不同之處在于DDR1的磷酸化過程異乎尋常地緩慢而持久。目前有多篇報道DDR1在原發性乳腺癌、卵巢癌、食管癌等人類腫瘤中過度表達,在兒童腦腫瘤中甚至可達到正常值的3倍,并且DDR1主要存在于高度浸潤性的腫瘤細胞中。研究亦發現,DDR1的過度表達和功能獲得性突變可增加腫瘤模型動物的致瘤性,而敲除DDR1基因會抑制腫瘤的發生和轉移。這些證據顯示DDR1很有可能是一個抗癌藥物開發的靶點。
更多DDR1相關閱讀:盤狀結構域受體DDR1:一種新型RTKs成員,腫瘤治療潛力靶標!
熱銷產品
The purity was greater than 95% as determined by SDS-PAGE. (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Immobilized Human DDR1 at 2 μg/ml can bind Anti-DDR1 recombinant antibody (CSB-RA006595MA1HU), the EC50 is 2.824-3.810 ng/mL
DDR1 Antibodies
DDR1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA198834 | DDR1 (Ab-796) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA978355 | DDR1 Antibody | Human | ELISA,WB |
| CSB-PA000715 | Phospho-DDR1 (Y513) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA002098 | DDR1 Antibody | Human | WB, ELISA |
| CSB-PA060123 | DDR1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-RA006595MA1HU | DDR1 Recombinant Monoclonal Antibody | Human | ELISA |
DDR1 Proteins
DDR1 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP730899RA CSB-EP730899RA CSB-BP730899RA CSB-MP730899RA CSB-EP730899RA-B |
Recombinant Rat Epithelial discoidin domain-containing receptor 1 (Ddr1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DDR1 Proteins for Pan troglodytes (Chimpanzee)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP771987EQV CSB-EP771987EQV CSB-BP771987EQV CSB-MP771987EQV CSB-EP771987EQV-B |
Recombinant Pan troglodytes Epithelial discoidin domain-containing receptor 1 (DDR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DDR1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-MP006595HU | Recombinant Human Epithelial discoidin domain-containing receptor 1 (DDR1), partial (Active) | Mammalian cell |






