FBXW7
FBXW7，全名為F-box and WD repeat domain containing 7，常見(jiàn)別名包括AGO、CDC4、FBW6、FBW7、FBX30、FBXO30、FBXW6和hAgo等。該蛋白屬于F-box蛋白家族，參與泛素化調(diào)控，通過(guò)識(shí)別底物并將其連接到泛素鏈上，促進(jìn)底物的降解。FBXW7蛋白在多種細(xì)胞過(guò)程中發(fā)揮重要作用，包括細(xì)胞周期調(diào)控、DNA損傷修復(fù)和腫瘤抑制等。相關(guān)研究表明，F(xiàn)BXW7蛋白在原發(fā)性肝癌、乳腺癌和結(jié)直腸癌等多種癌癥中表達(dá)下調(diào)，與腫瘤的發(fā)生發(fā)展密切相關(guān)。此外，F(xiàn)BXW7蛋白還參與Wnt信號(hào)通路和Notch信號(hào)通路的調(diào)控，影響細(xì)胞增殖、分化和凋亡等過(guò)程。針對(duì)FBXW7蛋白的藥物研發(fā)已取得一定進(jìn)展，例如開(kāi)發(fā)FBXW7抑制劑用于治療癌癥，以及利用FBXW7蛋白作為生物標(biāo)志物進(jìn)行疾病診斷和預(yù)后評(píng)估。
熱銷(xiāo)產(chǎn)品
FBXW7 Antibody (CSB-PA822163LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry analysis of human kidney tissue using CSB-PA822163LA01HU at dilution of 1:100
Immunocytochemistry analysis of human small intestine tissue using CSB-PA822163LA01HU at dilution of 1:100
FBXW7 Antibodies
FBXW7 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA251991 | FBXW7 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA623964 | FBXW7 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA822163LA01HU | FBXW7 Antibody | Human | ELISA, IHC |
| CSB-PA822163LB01HU | FBXW7 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA822163LD01HU | FBXW7 Antibody, Biotin conjugated | Human | ELISA |
FBXW7 Proteins
FBXW7 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP822163HU CSB-EP822163HU CSB-BP822163HU CSB-EP822163HU-B |
Recombinant Human F-box/WD repeat-containing protein 7 (FBXW7) | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
FBXW7 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP851809MO CSB-EP851809MO CSB-BP851809MO CSB-MP851809MO CSB-EP851809MO-B |
Recombinant Mouse F-box/WD repeat-containing protein 7 (Fbxw7) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FBXW7 Proteins for Homo sapiens(Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-CF822163HU | Recombinant Human F-box/WD repeat-containing protein 7 (FBXW7) | in vitro E.coli expression system |
