ICAM1

ICAM1，全稱Intercellular adhesion molecule 1，也稱為CD54、MALA-2等，是一種重要的細(xì)胞表面糖蛋白，主要表達(dá)于內(nèi)皮細(xì)胞和免疫細(xì)胞。它通過與其他細(xì)胞表面的受體結(jié)合，參與白細(xì)胞遷移和活化過程，對免疫應(yīng)答和炎癥反應(yīng)起著關(guān)鍵作用。ICAM1還與鼻病毒等病毒入侵細(xì)胞有關(guān)，并在多種疾病中發(fā)揮作用，如炎癥性腸病、甲狀腺癌、自身免疫性疾病等。近年來，針對ICAM1的藥物研發(fā)取得顯著進(jìn)展，例如德克薩斯大學(xué)MD安德森癌癥中心開發(fā)的新型CAR-T細(xì)胞療法AIC100，通過靶向ICAM1蛋白，在治療晚期甲狀腺癌方面展現(xiàn)出良好效果。此外，Ionis Pharmaceuticals Inc研發(fā)的antisense oligonucleotides ICAM-1 (Isis)也是一種ICAM1抑制劑，用于治療炎性疾病和腫瘤。這些進(jìn)展為ICAM1相關(guān)疾病的治療提供了新的希望。

熱銷產(chǎn)品

Recombinant Human Intercellular adhesion molecule 1 (ICAM1), partial (Active) (CSB-MP010949HU)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human ICAM1 at 2 μg/ml can bind Anti-ICAM1 recombinant antibody (CSB-RA010949MA1HU). The EC₅₀ is 0.2350-0.4911 ng/mL.

ICAM1 Recombinant Monoclonal Antibody (CSB-RA162789A0HU)

驗證數(shù)據(jù)

IHC image of CSB-RA162789A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

IHC image of CSB-RA162789A0HU diluted at 1:100 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Overlay histogram showing Raji cells surface stained with CSB-RA162789A0HU (red line) at 1:50. The cells were incubated in 10% normal goat serum to block non-specific protein-protein interactions followedby the antibody (1μg/1*10⁶ cells) for 1 h at 4℃.The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 30min at 4℃. Control antibody (green line) was Rabbit IgG (1μg/1*10⁶ cells) used under the same conditions. Acquisition of >10,000 events was performed.

Human intercellular adhesion molecule 1,ICAM-1 ELISA Kit (CSB-E04574h)

驗證數(shù)據(jù)

貨號：CSB-E04574h

規(guī)格：96T/48T

靈敏度：0.195 ng/mL

檢測范圍：0.78 ng/mL-50 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

ICAM1 Antibody

ICAM1 Protein

ICAM1 ELISA Kit

ICAM1 Antibodies

ICAM1 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA010949GA01HU	ICAM1 Antibody	Human	ELISA,WB,IHC
CSB-PA928596	Phospho-ICAM1 (Tyr512) Antibody	Human	ELISA,WB
CSB-PA918533	ICAM1 (Ab-512) Antibody	Human	ELISA,WB
CSB-PA000547	Phospho-ICAM1 (Y512) Antibody	Human	WB, ELISA
CSB-PA002997	ICAM1 Antibody	Human	WB, ELISA
CSB-PA238929	ICAM1 Antibody	Human	ELISA,WB,IHC
CSB-PA598794	ICAM1 Antibody	Human	ELISA,WB,IHC
CSB-PA584826	ICAM1 Antibody	Human	ELISA,WB,IHC
CSB-PA793095	ICAM1 Antibody	Human	ELISA,WB,IHC
CSB-PA07149A0Rb	ICAM1 Antibody	Human, Rat	ELISA, WB, IHC, IF
CSB-PA07149B0Rb	ICAM1 Antibody, HRP conjugated	Human	ELISA
CSB-PA07149C0Rb	ICAM1 Antibody, FITC conjugated	Human
CSB-PA07149D0Rb	ICAM1 Antibody, Biotin conjugated	Human	ELISA
CSB-MA211660	ICAM1 Monoclonal Antibody	Human	ELISA, IHC
CSB-RA162789A0HU	ICAM1 Recombinant Monoclonal Antibody	Human	ELISA, IHC, FC
CSB-RA010949MA1HU	ICAM1 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, FC

ICAM1 Proteins

ICAM1 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP010949RA1 CSB-EP010949RA1 CSB-BP010949RA1 CSB-MP010949RA1 CSB-EP010949RA1-B	Recombinant Rat Intercellular adhesion molecule 1 (Icam1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF010949RA	Recombinant Rat Intercellular adhesion molecule 1 (Icam1)	in vitro E.coli expression system

ICAM1 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP010949MO1 CSB-EP010949MO1 CSB-BP010949MO1 CSB-MP010949MO1 CSB-EP010949MO1-B	Recombinant Mouse Intercellular adhesion molecule 1 (Icam1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF010949MO	Recombinant Mouse Intercellular adhesion molecule 1 (Icam1)	in vitro E.coli expression system

ICAM1 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP010949DO1 CSB-EP010949DO1 CSB-BP010949DO1 CSB-MP010949DO1 CSB-EP010949DO1-B	Recombinant Dog Intercellular adhesion molecule 1 (ICAM1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF010949DO	Recombinant Dog Intercellular adhesion molecule 1 (ICAM1)	in vitro E.coli expression system

ICAM1 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP010949HU CSB-BP010949HU CSB-EP010949HU-B	Recombinant Human Intercellular adhesion molecule 1 (ICAM1), partial	Yeast Baculovirus In Vivo Biotinylation in E.coli
CSB-EP010949HU	Recombinant Human Intercellular adhesion molecule 1 (ICAM1), partial	E.coli
CSB-CF010949HU(A4)	Recombinant Human Intercellular adhesion molecule 1 (ICAM1)	in vitro E.coli expression system
CSB-MP010949HU	Recombinant Human Intercellular adhesion molecule 1 (ICAM1), partial (Active)	Mammalian cell

ICAM1 Proteins for Pan paniscus (Pygmy chimpanzee) (Bonobo)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP010949EQU CSB-EP010949EQU CSB-BP010949EQU CSB-MP010949EQU CSB-EP010949EQU-B	Recombinant Pan paniscus Intercellular adhesion molecule 1 (ICAM1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ICAM1 Proteins for Bos taurus (Bovine)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP010949BO CSB-EP010949BO CSB-BP010949BO CSB-MP010949BO CSB-EP010949BO-B	Recombinant Bovine Intercellular adhesion molecule 1 (ICAM1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ICAM1 Proteins for Pan troglodytes (Chimpanzee)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP010949EQV CSB-EP010949EQV CSB-BP010949EQV CSB-MP010949EQV CSB-EP010949EQV-B	Recombinant Pan troglodytes Intercellular adhesion molecule 1 (ICAM1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ICAM1 Proteins for Gorilla gorilla gorilla (Lowland gorilla)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP010949GGZ CSB-EP010949GGZ CSB-BP010949GGZ CSB-MP010949GGZ CSB-EP010949GGZ-B	Recombinant Gorilla gorilla gorilla Intercellular adhesion molecule 1 (ICAM1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ICAM1 Proteins for Macaca mulatta (Rhesus macaque)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP010949MOW CSB-EP010949MOW CSB-BP010949MOW CSB-MP010949MOW CSB-EP010949MOW-B	Recombinant Macaca mulatta Intercellular adhesion molecule 1 (ICAM1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ICAM1 ELISA Kit

ICAM1 ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)

產(chǎn)品貨號	產(chǎn)品名稱	樣本類型	靈敏度
CSB-E08898c	Dog intercellular adhesion molecule 1,ICAM-1/CD54 ELISA Kit	serum, plasma, tissue homogenates	6.25 ng/mL

ICAM1 ELISA Kit for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	樣本類型	靈敏度
CSB-E04574h	Human intercellular adhesion molecule 1,ICAM-1 ELISA Kit	serum, plasma, tissue homogenates	0.195 ng/mL
CSB-E04574h-IS	Human intercellular adhesion molecule 1,ICAM-1 ELISA Kit	serum, plasma, tissue homogenates	0.156ng/mL