KIT

Kit，全稱為酪氨酸激酶受體c-Kit，是一種重要的細胞表面受體，在多種生理和病理過程中發揮關鍵作用。常見別名包括CD117和SCFR。Kit蛋白參與多種細胞功能，如細胞增殖、分化、存活和遷移，對造血細胞、肥大細胞和黑色素細胞的發育至關重要。在腫瘤發生中，Kit蛋白的突變會導致其持續激活，進而引發細胞不受控制地增殖，與胃腸道間質瘤（GIST）、黑色素瘤、急性髓細胞性白血病等多種癌癥密切相關。針對Kit蛋白的藥物研發已成為癌癥治療的重要方向。目前，已有多種Kit抑制劑被開發出來，如伊馬替尼、舒尼替尼和瑞戈非尼等，它們通過抑制Kit蛋白的活性，有效控制腫瘤細胞的生長。此外，新型藥物如瑞派替尼和avapritinib等，則針對Kit蛋白的不同突變體，展現出更高的選擇性和療效。這些藥物的研發和應用，為Kit蛋白突變相關的癌癥患者提供了新的治療選擇，顯著改善了患者的預后。

熱銷產品

Recombinant Human Mast/stem cell growth factor receptor Kit (KIT), partial (CSB-MP012375HU)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

KIT Recombinant Monoclonal Antibody (CSB-RA012375MA1HU)

驗證數據

IHC image of CSB-RA012375MA1HU diluted at 1：100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.

Overlay Peak curve showing JK cells stained with CSB-RA012375MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*10⁶cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-human IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was human IgG (1ug/1*10⁶cells) used under the same conditions. Acquisition of >10,000 events was performed.

KIT Antibody (CSB-PA07109A0Rb)

驗證數據

Immunofluorescent analysis of MCF-7 cells using CSB-PA07109A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Human Stem Cell Factor Receptor,SCFR ELISA kit (CSB-E04721h)

驗證數據

貨號：CSB-E04721h

規格：96T/48T

靈敏度：0.39 ng/mL

檢測范圍：1.56 ng/mL-100 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

KIT Antibody

KIT Protein

KIT ELISA Kit

KIT Antibodies

KIT for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA012375GA01HU	KIT Antibody	Human	ELISA,WB,IHC
CSB-PA449794	Phospho-KIT (Tyr721) Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA437024	Phospho-KIT (Tyr936) Antibody	Human	ELISA,WB,IHC
CSB-PA060048	KIT (Ab-936) Antibody	Human	ELISA,WB,IHC
CSB-PA040159	Phospho-KIT (Tyr703) Antibody	Human,Mouse	ELISA,WB
CSB-PA000502	Phospho-KIT (Y721) Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA009645	Phospho-KIT (Y936) Antibody	Human,Mouse	WB, IHC, ELISA
CSB-PA009647	Phospho-KIT (Y703) Antibody	Human,Mouse	WB, IHC, ELISA
CSB-PA009648	KIT Antibody	Human,Mouse	WB, IHC, ELISA
CSB-PA009649	KIT Antibody	Human,Mouse,Rat,Monkey	WB, IF, ELISA
CSB-PA442757	KIT Antibody	Human,Mouse	ELISA,IHC
CSB-PA07109A0Rb	KIT Antibody	Human	ELISA, IF
CSB-PA07109B0Rb	KIT Antibody, HRP conjugated	Human	ELISA
CSB-PA07109C0Rb	KIT Antibody, FITC conjugated	Human
CSB-PA07109D0Rb	KIT Antibody, Biotin conjugated	Human	ELISA
CSB-RA012375MA1HU	KIT Recombinant Monoclonal Antibody	Human	ELISA, IHC, FC

KIT Proteins

KIT Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP012375HU CSB-EP012375HU CSB-BP012375HU CSB-EP012375HU-B	Recombinant Human Mast/stem cell growth factor receptor Kit (KIT), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-MP012375HU	Recombinant Human Mast/stem cell growth factor receptor Kit (KIT), partial	Mammalian cell

KIT Proteins for Bos taurus (Bovine)

產品貨號	產品名稱	來源
CSB-YP012375BO CSB-EP012375BO CSB-BP012375BO CSB-MP012375BO CSB-EP012375BO-B	Recombinant Bovine Mast/stem cell growth factor receptor Kit (KIT), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KIT Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP012375MO CSB-EP012375MO CSB-BP012375MO CSB-EP012375MO-B	Recombinant Mouse Mast/stem cell growth factor receptor Kit (Kit), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli

KIT Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

產品貨號	產品名稱	來源
CSB-YP012375DO CSB-EP012375DO CSB-BP012375DO CSB-MP012375DO CSB-EP012375DO-B	Recombinant Dog Mast/stem cell growth factor receptor Kit (KIT), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KIT Proteins for Gallus gallus (Chicken)

產品貨號	產品名稱	來源
CSB-YP600460CH CSB-EP600460CH CSB-BP600460CH CSB-MP600460CH CSB-EP600460CH-B	Recombinant Chicken Mast/stem cell growth factor receptor Kit (KIT), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KIT Proteins for Felis catus (Cat) (Felis silvestris catus)

產品貨號	產品名稱	來源
CSB-YP631732CA CSB-EP631732CA CSB-BP631732CA CSB-MP631732CA CSB-EP631732CA-B	Recombinant Cat Mast/stem cell growth factor receptor Kit (KIT), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KIT Proteins for Capra hircus (Goat)

產品貨號	產品名稱	來源
CSB-YP636717GO CSB-EP636717GO CSB-BP636717GO CSB-MP636717GO CSB-EP636717GO-B	Recombinant Goat Mast/stem cell growth factor receptor Kit (KIT), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KIT Proteins for Sus scrofa (Pig)

產品貨號	產品名稱	來源
CSB-YP639474PI CSB-EP639474PI CSB-BP639474PI CSB-MP639474PI CSB-EP639474PI-B	Recombinant Pig Mast/stem cell growth factor receptor Kit (KIT), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KIT Proteins for Callithrix jacchus (White-tufted-ear marmoset)

產品貨號	產品名稱	來源
CSB-YP765733CYL CSB-EP765733CYL CSB-BP765733CYL CSB-MP765733CYL CSB-EP765733CYL-B	Recombinant Callithrix jacchus Mast/stem cell growth factor receptor Kit (KIT), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KIT Proteins for Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)

產品貨號	產品名稱	來源
CSB-YP805842TKY CSB-EP805842TKY CSB-BP805842TKY CSB-MP805842TKY CSB-EP805842TKY-B	Recombinant Takifugu rubripes Mast/stem cell growth factor receptor Kit (kit), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KIT Proteins for Xenopus laevis (African clawed frog)

產品貨號	產品名稱	來源
CSB-YP841978XBE CSB-EP841978XBE CSB-BP841978XBE CSB-MP841978XBE CSB-EP841978XBE-B	Recombinant Xenopus laevis Mast/stem cell growth factor receptor-related protein Kit (kit), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli