SIRT6
SIRT6全稱為沉默調(diào)節(jié)蛋白6，是sirtuin家族成員之一，因其依賴輔酶NAD+發(fā)揮去乙酰化酶活性，又被稱作NAD依賴性組蛋白去乙酰化酶。SIRT6在基因組穩(wěn)定性維持和代謝調(diào)控中發(fā)揮核心作用，通過(guò)修復(fù)DNA損傷、調(diào)控糖脂代謝相關(guān)基因表達(dá)延緩細(xì)胞衰老進(jìn)程。研究發(fā)現(xiàn)SIRT6缺失會(huì)引發(fā)早衰綜合征，其表達(dá)異常與肝癌、結(jié)腸癌等惡性腫瘤轉(zhuǎn)移密切相關(guān)，同時(shí)在Ⅱ型糖尿病、動(dòng)脈粥樣硬化等代謝性疾病中呈現(xiàn)顯著下調(diào)趨勢(shì)。近年研究發(fā)現(xiàn)該蛋白可抑制NF-κB通路減輕慢性炎癥，并通過(guò)激活A(yù)MPK通路改善胰島素抵抗。當(dāng)前針對(duì)SIRT6的藥物開(kāi)發(fā)聚焦于小分子激活劑，如化合物MDL-800已在動(dòng)物模型中證實(shí)可增強(qiáng)DNA修復(fù)能力并延長(zhǎng)壽命，而部分天然產(chǎn)物如白藜蘆醇衍生物也顯示出調(diào)控潛力。隨著PROTAC等新技術(shù)的應(yīng)用，靶向SIRT6的雙功能分子正成為抗衰老和癌癥治療領(lǐng)域的研究熱點(diǎn)。
熱銷產(chǎn)品
Recombinant Human NAD-dependent protein deacetylase sirtuin-6 (SIRT6) (CSB-EP854057HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗(yàn)證數(shù)據(jù)
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse stomach tissue, Primary antibody: CSB-PA959450(SIRT6 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
SIRT6 Antibodies
SIRT6 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA021344GA01HU | SIRT6 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA854057ESR2HU | SIRT6 Antibody | Human | ELISA |
| CSB-PA959450 | SIRT6 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA113703 | SIRT6 Antibody | Human,Mouse | ELISA,WB |
SIRT6 Proteins
SIRT6 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP021344MO CSB-EP021344MO CSB-BP021344MO CSB-MP021344MO CSB-EP021344MO-B |
Recombinant Mouse NAD-dependent protein deacetylase sirtuin-6 (Sirt6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SIRT6 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP854057HU CSB-BP854057HU CSB-MP854057HU CSB-EP854057HU-B |
Recombinant Human NAD-dependent protein deacetylase sirtuin-6 (SIRT6) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP854057HU | Recombinant Human NAD-dependent protein deacetylase sirtuin-6 (SIRT6) | E.coli |
SIRT6 ELISA Kit
SIRT6 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E17018h | Human NAD-dependent deacetylase sirtuin-6 (SIRT6/SIR2L6) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 0.78 pg/mL |
